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"Indication for Ganciclovir Therapy in a Schizophrenic
Patient"
Abstract of Presentation at the 4th Symposium on
the Neurovirology and Neuroimmunology of
Schizophrenia and Bipolar Disorder
Maryland, November 1998
Authors: W. John Martin (presentor), Jeffrey C. Kopelson, Donovan J.
Anderson
Blood cultures from hospitalized patients with severe psychiatric disorders, including
schizophrenia and manic depression, have confirmed the high prevalence of infection with
stealth viruses. These agents induce a characteristic, vacuolating, cytopathic effect in
normal fibroblasts. Similar cytopathic effects have been seen in cultures of blood,
cerebrospinal fluid, and tissue biopsies of patients with chronic fatigue syndrome (CFS)
and with more overt neurological illnesses. In preliminary studies involving small groups
of non-psychotic patients, clinical improvements have been noted following a brief course
of ganciclovir therapy. This observation is consistent with data that at least some
stealth viruses contain herpesvirus-related sequences. It is therefore proposed to treat a
stealth virus culture-positive, psychotic patient with a 21-day course of ganciclovir
administered intravenously. The particular patients illness began in 1987 at age 17,
when she was briefly hospitalized for a mononucleosis-like syndrome. Her personality
gradually changed as she became increasingly depressed and lethargic, leading to a
diagnosis of CFS. She also experienced recurrent rage and panic reactions. Paranoid
delusional thinking and both visual and auditory hallucinations led in 1990 to a diagnosis
of schizophrenia. Hypothyroidism, complex partial seizures, tremor, and dementia have also
been documented. The patient has been under custodial care in locked facilities for the
last several years. During the planned ganciclovir therapy, she will be followed for signs
of clinical improvement in sensory, motor, autonomic, cognitive, and emotional functions.
Her blood will also be monitored using a quantitative stealth virus culture assay.
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